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The vaccine is given by injection. An initial dose provides protection starting two to four weeks after vaccination; the second booster dose, given six to twelve months later, provides protection for over twenty years.<ref name=Avaxim /><ref name=CDC_2006 />
===Vaccination programmes===
The vaccine was introduced in 1992 and was initially recommended for persons at high risk. Since then Bahrain and Israel have embarked on eradication programmes.<ref name=André2006>André FE (2006) Universal mass vaccination against hepatitis A. Curr Top Microbiol Immunol 304:95-114</ref> Australia, China, Byelorussia, Italy, Spain and the United States have started similar programmes. The incidence of Hepatitis A where widespread vaccination has been practised has decreased dramatically. In China and the United States the incidence of Hepatitis A has decreased by 90% since 1990.<ref name=Cui2009>Cui F, Hadler SC, Zheng H, Wang F, Zhenhua W, Yuansheng H, Gong X, Chen Y, Liang X (2009) Hepatitis A surveillance and vaccine use in China from 1990 through 2007. J Epidemiol 19(4):189-195</ref><ref name=Daniels2009>Daniels D, Grytdal S, Wasley A (2009) Surveillance for acute viral hepatitis - United States, 2007. MMWR Surveill Summ 58(3):1-27</ref>
== Treatment ==
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